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What is zolpidem, why’s it used and what’s the recommended dose?

Buy zolpidem online uk. Zolpidem is a sleeping pill that’s routinely prescribed for the short-term treatment of insomnia.

It’s one of the so-called Z drugs, alongside zopiclone and zaleplon, which were originally developed as safer alternatives to benzodiazepines. Zolpidem is a hypnotic agent, which means that it can induce sleep.

In America, it’s more commonly known by the brand name Ambien and in the UK it’s also called Stilnoct. It’s only available on prescription.

The standard adult dose is 10mg daily for up to four weeks, with the drug to be taken at bedtime. However, 5mg daily for up to four weeks is recommended for the elderly. The NICE website has information on Zolpidem which you can find here.

Buy zolpidem online uk. How zolpidem works and how it might affect you

Zolpidem is a fast-acting medication, which usually begins to make you feel sleepy within an hour of taking it.

It’s considered to be a short-acting hypnotic, which means that while it may help you fall asleep quicker, it may not necessarily help you to sleep longer as its effects wear off fairly quickly.

Zolpidem decreases how long it takes to fall asleep, improves sleep quality, increases stage N2 and N3 slow-wave sleep and reduces night‐time awakenings.¹

In healthy adults, a study showed that a 10mg dose of zolpidem:

• reduced the number of awakenings and wake after sleep onset (WASO)
• improved sleep efficiency
• improved most subjective sleep measures relative to placebo.

Psychomotor performance and subjective assessment of morning sleepiness and morning concentration were not affected. Buy zolpidem online uk.

In this study, people taking zolpidem did not become tolerant to the drug or experience a rebound effect (i.e. a recurrence of sleep problems with worse symptoms) after using the recommended dosage for five weeks.

Zolpidem can be taken in several different ways

Zolpidem can be prescribed as a pill, in a form that dissolves under the tongue or as a mouth spray.

It’s also available in a modified formulation that leads to an extended release of the drug during the night. We’ll have a look at the different formulations and why they were developed.

Modified‐release (MR) formulation of zolpidem

Because of its short duration of action and inconsistent effects on sleep maintenance, a modified-release version of zolpidem has been developed that releases the drug throughout the night.

Zolpidem‐MR has been marketed in the United States since 2005 — somewhat confusingly under the name Ambien CR. Buy zolpidem online uk.

Zolpidem-MR is a two-layered tablet. It has one layer that’s released immediately after taking it, which leads to a zolpidem concentration in the body similar to the original formulation.

This is followed by the second layer, which provides an extended release of zolpidem to maintain levels of the drug through the middle of the night.

The dosage is also slightly different to that of the standard formulation, with the starting dose of Zolpidem-MR being 12.5mg for adults and 6.25mg for the elderly.³

This formulation is intended to help people who wake in the night, as it provides a longer release of zolpidem.

A study found that Zolpidem-MR at 12.5mg provided sustained and significant improvements in sleep onset and maintenance and improved next‐day concentration and morning sleepiness for up to six months.⁴

Zolpidem-MR has a safety profile comparable to the original, immediate-release formulation. and has not been shown to significantly affect psychomotor and cognitive performance eight hours post-dose. Buy zolpidem online uk.

Buy zolpidem online uk. Zolpidem as a sublingual tablet

Zolpidem is also available as a sublingual tablet that is placed under the tongue and allowed to dissolve completely before swallowing.

Common brand names of this form include Edluar and Intermezzo. Zolpidem for sublingual use is not to be swallowed whole and shouldn’t be taken with or immediately after a meal.

This mode of drug delivery allows zolpidem to be used to treat middle-of-the-night insomnia when an awakening is followed by difficulty returning to sleep.

However, it shouldn’t be taken if you have less than four hours of sleep time remaining, as it could interfere with your daily functioning if taken too close to when you wake up. Buy zolpidem online uk.

Buy zolpidem online uk. Zolpidem as an oral mist

Zolpidem oral mist (brand name ZolpiMist) is also available. This formulation is sprayed into your mouth and over your tongue, usually once a night, and provides an alternative way of taking the drug.⁷

It should be taken just before you get into bed. Unlike the sublingual tablets, this product is not for use in the middle of the night and should only be used if you have time for a whole night’s sleep of at least 7-8 hours.

The recommended dose is no higher than 10mg a day — the same as the standard zolpidem tablets.

Is zolpidem a safe way to treat sleep problems?

Numerous studies have demonstrated a good safety profile for zolpidem compared to benzodiazepine-class drugs. It’s a safe and effective drug when taken at the recommended dosage. Buy zolpidem online uk.

Zolpidem is however known to interact with drugs that primarily have sedative properties. Current NHS guidelines state that you should check with your healthcare provider or pharmacist if you are already taking:

• drowsy antihistamines such as chlorphenamine or promethazine
• medicines to treat schizophrenia and bipolar disorder
• medicines to treat depression
• medicines for epilepsy
• medicines to calm or reduce anxiety
• medicines for sleep problems
• medicines used to treat fungal infections (such as ketoconazole and itraconazole)
• ritonavir (a medicine used to treat HIV infections)
• strong painkillers (such as codeine, methadone, morphine, oxycodone, pethidine or tramadol).⁸

Due to concerns over tolerance, dependence and withdrawal effects, the current NICE guidelines do not recommend the use of any hypnotic drugs, including zolpidem, for periods of more than four weeks. Buy zolpidem online uk.

Buy zolpidem online uk. Longer term use of zolpidem

While it’s advised only to be used in the short term, several studies suggest that zolpidem in the dose range of 5 -10mg is safe even for extended treatment periods.⁹

One study looked at the effects of taking zolpidem nightly for eight months as a treatment for primary insomnia. The results showed that the drug stayed effective at improving the sleep of participants during this period, without tolerance to the drug becoming an issue.^9 10

Further research on the extended use of zolpidem has shown no clinically significant withdrawal symptoms after 12 months of nightly use.¹⁰

In this work, the authors concluded that chronic nightly use of zolpidem, at therapeutic doses by people with primary insomnia, does not lead to rebound insomnia or withdrawal symptoms after treatment was over. Buy zolpidem online uk.

One of the issues with many sleeping tablets is the potential for tolerance to the effects of the drug, which leads to people needing to take higher and higher doses of the medication to get the same effect.

However, a study has shown that chronic use of zolpidem by primary insomniacs did not lead to dose escalation during 12 months of nightly use,¹⁰ suggesting a low potential for tolerance in this time frame.

Buy zolpidem online uk. The side effects of zolpidem

There are numerous side effects associated with taking this drug. Common or very common side effects of zolpidem include:

• abdominal pain
• anterograde amnesia
• anxiety
• back pain
• diarrhoea
• dizziness
• fatigue
• hallucination
• headache
• increased risk of infection
• nausea
• sleep disorders
• vomiting.¹¹

Less common side effects include poor motor coordination, difficulty maintaining balance, increased appetite, increased libido, impaired judgment and reasoning.