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Each tablet contains 500mg paracetamol and 10mg dihydrocodeine tartrate

For the full list of excipients see section 6.1.

Tablet.

Flat bevelled edge white tablets marked S/8 on one side

For the relief of mild to moderate pain.

Posology

Adults and children over 16 years: One to two tablets every four to six hours when necessary up to a maximum of eight tablets in 24 hours.

Elderly: As for adults, however a reduced dose maybe required if renal or hepatic function is impaired.

Prior to starting treatment with opioids, a discussion should be held with patients to put in place a strategy for ending treatment with dihydrocodeine in order to minimise the risk of addiction and drug withdrawal syndrome (see section 4.4). Buy Co Dydramol 10/500mg online uk.

Paediatric population

Children aged 12 to 15 years: One tablet every four to six hours when necessary to a maximum of four tablets in 24 hours.

Not recommended for children under 12 years of age.

Method of administration

For oral administration.

Co-dydramol Tablets must not be given to patients with respiratory depression, chronic obstructive airways disease or liver disease.

Hypersensitivity to the active substances or any of the excipients listed in section 6.1.

Dihydrocodeine may bring about histamine release, therefore it should not be given during an asthma attack and it should be administered with due care to persons liable to such attack. The dosage should be reduced in hypothyroidism and in renal insufficiency.

Alcohol should be avoided. When dihydrocodeine is prescribed for chronic use, care should be taken to avoid unnecessary increase in dosage.

Care is advised in the administration of paracetamol to patients with severe renal or severe hepatic impairment. The hazards of overdose are greater in those with alcoholic liver disease. Patients should be advised not to exceed the recommended dose and not to take other paracetamol-containing products concurrently. Buy Co Dydramol 10/500mg online uk

Caution is advised if paracetamol is administered concomitantly with flucloxacillin due to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, malnutrition and other sources of glutathione deficiency (e.g. chronic alcoholism), as well as those using maximum daily doses of paracetamol. Close monitoring, including measurement of urinary 5-oxoproline, is recommended.

The risk-benefit of continued use should be assessed regularly by the prescriber.

The leaflet will state in a prominent position in the ‘before taking’ section:

• Do not take for longer than your doctor tells you to. Buy Co Dydramol 10/500mg online uk

• This medicine contains paracetamol. Do not take anything else containing paracetamol while taking this medicine. Taking a painkiller for headaches too often or for too long can make them worse.

The label will state (To be displayed prominently on outer pack – not boxed):

• Do not take for longer than directed by your prescriber as taking dihydrocodeine regularly for a long time can lead to addiction.

• Do not take anything else containing paracetamol while taking this medicine. Talk to a doctor at once if you take too much of this medicine even if you feel well.

4.5. Interaction with other medicinal products and other forms of interaction